Turning back the clock on neural progenitors.

BioEssays : news and reviews in molecular, cellular and developmental biology

PubMedID: 15221852

Carr AR, Choksi SP, Brand AH. Turning back the clock on neural progenitors. Bioessays. 2004;26(7):711-4.
Drosophila neural progenitor cells, or neuroblasts, alter their transcriptional profile over time to produce different neural cell types. A recent paper by Pearson and Doe shows that older neuroblasts can be reprogrammed to behave like young neuroblasts, and to produce early neural cell types, simply by expressing the transcription factor, Hunchback. The authors show that competence to respond to Hunchback diminishes over time. Manipulating neural progenitors in this way may have important implications for therapeutic uses of neural stem cells.