Toward the total synthesis of phorboxazole B: an efficient synthesis of the C20-C46 segment.

Organic letters

PubMedID: 15524458

Li DR, Sun CY, Su C, Lin GQ, Zhou WS. Toward the total synthesis of phorboxazole B: an efficient synthesis of the C20-C46 segment. Org Lett. 2004;6(23):4261-4.
An efficient synthesis of the C20-C46 segment of phorboxazole B is described. The key steps involved Hg(OAc)(2)/I(2)-induced cyclization to construct the cis-tetrahydropyran moiety, the coupling of the metalated 2-methyloxazole 7 with lactone 6, and Julia olefination to furnish the conjugated diene moiety.