Transcriptional control of the testis-specific histone H1t gene.

Gene

PubMedID: 12568711

Grimes SR, Wilkerson DC, Noss KR, WOLFE SA. Transcriptional control of the testis-specific histone H1t gene. Gene. 2003;30413-21.
The mammalian testis-specific linker histone H1t is synthesized only in pachytene primary spermatocytes during spermatogenesis. In this review we summarize some of the progress made in our laboratory and in other laboratories in understanding transcriptional regulation of this gene. The gene is transcriptionally active in pachytene primary spermatocytes and is repressed in all other germinal and non-germinal cell types. To place the transcriptional control of the testis-specific histone H1t gene in the proper context, we briefly review recent literature concerning mammalian linker histone genes in general and we compare and contrast these with the testis-specific histone H1t gene.