Existence of alpha-adrenoceptor subtypes in isolated human gastroepiploic and omental arteries.

Circulation journal : official journal of the Japanese Circulation Society

PubMedID: 12604878

Fukui D, Chiba S. Existence of alpha-adrenoceptor subtypes in isolated human gastroepiploic and omental arteries. Circ J. 2003;67(3):259-62.
Establishing the existence of alpha-adrenoceptor subtypes in isolated human gastroepiploic and omental arteries was the goal of the present study. Functional vascular reactivity of selective alpha(1)- and alpha(2)-adrenoceptor agonists and antagonists was studied, using a cannula inserting technique. Intraluminal administration of norepinephrine (NE), phenylephrine (PE) or BHT-933 caused a vasoconstrictive response in a dose-related manner. The relative potencies of the 3 agonists were almost the same in both arteries. NE-induced vasoconstrictions were significantly antagonized by either prazosin or rauwolscine. PE-induced responses were strongly inhibited by prazosin. BHT-933-induced constrictions were inhibited by rauwolscine. These results indicate that both alpha(1)- and alpha(2)-adrenoceptors exist in the human gastroepiploic and omental arteries.