[Rhythm of expression of BCL-2 protein of MA13/C mammaryadenocarcinoma bearing-mice].

Pathologie-biologie

PubMedID: 12852995

Granda TG, Filipski E, Vrignaud P, Bissery MC, Lévi F. [Rhythm of expression of BCL-2 protein of MA13/C mammaryadenocarcinoma bearing-mice]. Pathol Biol. 2003;51(4):220-1.
We previously demonstrated a circadian rhythm in response to docetaxel chemotherapy in C3H/HeN mice bearing MA13/C mammary adenocarcinoma. We investigated the relation between this rhythm and the expression of BCL-2 in bone marrow and in tumor tissues. A circadian rhythm characterized BCL-2 expression in the bone marrow, which was hardly modified in tumor-bearing animals. BCL-2 acrophase coincided with the time of highest docetaxel tolerability and efficacy in this model. This suggests that BCL-2 protects the bone marrow from the drug toxicity, especially during the light phase.