[The role of nitric oxide in the cytotoxic effect of macrophages].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

PubMedID: 15182663

Zhang J, Zhou CC, Su B. [The role of nitric oxide in the cytotoxic effect of macrophages]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2003;19(6):604-5.
AIM
To explore the role of nitric oxide (NO) in cytotoxicity of macrophages.

METHODS
20 mice of Kunming species were divided into two groups. One group were injected subcutaneously with rhabdosarcoma cells S180 and the other were normal controls. The macrophages in peritoneal lavage fluid of two groups of mice were co-cultured with tumor cells K562. L-arginine(L-Arg) or NG nitro L-arginine methyleste(L-NAME) was added to the culture medium, and the cytotoxicity of macrophages was measured.

RESULTS
Macrophages from tumor bearing mice had stronger cytotoxicity than those from normal mice. L-Arg increased and L-NAME decreased the cytotoxicity of macrophages from tumor bearing mice, but both had no effect on the cytotoxicity of macrophages from normal mice.

CONCLUSION
NO is an effector molecule in cytotoxicity of activated macrophages.