Recovery of injured adrenal medulla by differentiation of pre-existing undifferentiated chromaffin cells.

Toxicologic pathology

PubMedID: 11950159

Chen-Pan C, Pan IJ, Yamamoto Y, Chen HH, Hayashi Y. Recovery of injured adrenal medulla by differentiation of pre-existing undifferentiated chromaffin cells. Toxicol Pathol. 2002;30(2):165-72.
We described previous that the adrenal medulla recovers rapidly from the injuries due to salinomycin. In the present study we found the recovery to be apparently due to differentiation of pre-existing, primitive undifferentiated, chromaffin cells, rather than mitosis, as evidenced by lack of incorporation of 5-bromo-2-deoxyuridine in the differentiating and/or differentiated chromaffin cells. Electron-dense, striated fibrils observed within the necrotic cells and in the extracellular space were presumed to be intermediate degradation products. Schwann cells actively functioned as phagocytes in this study, and seemed to indirectly stimulate the differentiation of undifferentiated chromaffin cells.