[Evaluation of TGF-beta1 expressed by oral and maxillofacial malignant neoplasm].

Shanghai kou qiang yi xue = Shanghai journal of stomatology

PubMedID: 14983258

Li Q, Zhou XJ, Zhang ZY, Patima , Chen WT. [Evaluation of TGF-beta1 expressed by oral and maxillofacial malignant neoplasm]. Shanghai Kou Qiang Yi Xue. 2002;11(3):233-6.
OBJECTIVE
To investigate the relationship between the level of transforming growth factor beta I(TGF-beta(1)) in oral and maxillofacial malignant neoplasms and the biological characteristics of these carcinoma cells.

METHODS
The level of TGF-beta(1) in the carcinoma tissue cells, human tongue squamous cell carcinoma cell line Tca8113, human minor salivary gland carcinoma cell line ACC-2 and highly metastatic adenoid cystocarcinoma cell line ACC-M was measured by ELISA KIT.

RESULTS
The level of TGF-beta(1) in the carcinoma tissue cells had significant difference to that of normal cells(P<0.01). The level in Tca8113 and ACC-2 cells was significantly higher(P<0.05). Squamous cell carcinoma cell line Tca8113 had the same level of TGF-beta(1) as the adenoid cystocarcinoma cell line ACC-2, but the highly metastatic adenoid cystocarcinoma cells(ACC-M) expressed far less compared to ACC-2 cells (P<0.01). The level of TGF-beta(1) secreted by ACC-M cells to the culture without serum was also lower than that of any of the other carcinoma cells or normal cells.

CONCLUSION
The level of TGF-beta(1) expression had significant relation to the proliferation, invasion and metastasis of oral and maxillofacial malignant neoplasms.