[Estrogen and bone metabolism--basic research].

Clinical calcium

PubMedID: 15775420

Kawano H, Kawaguchi H. [Estrogen and bone metabolism--basic research]. Clin Calcium. 2002;12(9):1237-45.
Biological functions of estrogen are exerted mainly through binding to the nuclear receptors, estrogen receptor alpha, beta (ERalpha, beta) , which regulate the transcription of target genes. Recent studies have revealed its direct effect on bone at molecular level, which is mediated by a complicated network of various cytokines. In addition, it is suggested not only that both estrogen and androgen have independent roles in bone metabolism, but also they have common non-genotropic and anti-apoptotic pathways in bone cells.