A new approach to oligonucleotide labelling using Diels-Alder cycloadditions and detection by SERRS.

Chemical communications (Cambridge, England)

PubMedID: 12357797

Fruk L, Grondin A, Smith WE, Graham D. A new approach to oligonucleotide labelling using Diels-Alder cycloadditions and detection by SERRS. Chem Commun (Camb). 2002;(18):2100-1.
Diels-Alder cycloaddition has been used to add a benzotriazole azo dye to a diene tagged oligonucleotide to generate unique SERRS signals at 10 attomoles.