Mouse models of abnormal skeletal development and homeostasis.

Trends in genetics : TIG

PubMedID: 11585675

McLean W, Olsen BR. Mouse models of abnormal skeletal development and homeostasis. Trends Genet. 2001;17(10):S38-43.
Studies of a number of mouse mutations with skeletal defects have contributed significantly to the understanding of bone development and homeostasis. In many cases, such mutants are also genetic models of disorders in humans, characterized by reduced bone mass (osteoporosis), increased bone mass (osteopetrosis), or abnormalities in endochondral ossification (chondrodysplasias).