Dynamics of neural networks: a proposed mechanism to account for changes in clinical symptomatology through time in patients with psychotic diseases.

Medical hypotheses

PubMedID: 11601866

Dubrovsky B. Dynamics of neural networks: a proposed mechanism to account for changes in clinical symptomatology through time in patients with psychotic diseases. Med Hypotheses. 2001;57(4):439-45.
The classical Kraepelinean dichotomy between manic depressive insanity and the schizophrenias has been recently challenged from clinical and neurobiological quarters. It is not so infrequent to see patients shift from a manic to a schizophrenic symptomatology and vice versa. This paper proposes neurobiological mechanisms as to how these changes may occur, based on recent data on the functioning of neural networks at different modes.