Effect of grepafloxacin on cytokine production in vitro.

The Journal of antimicrobial chemotherapy

PubMedID: 10882695

Ono Y, Ohmoto Y, Ono K, Sakata Y, Murata K. Effect of grepafloxacin on cytokine production in vitro. J Antimicrob Chemother. 2000;46(1):91-4.
The effect of a new quinolone antibacterial agent, grepafloxacin, on the production of cytokines was investigated using lipopolysaccharide-stimulated human peripheral blood cells. Grepafloxacin 1-30 mg/L inhibited the production of interleukin 1alpha (IL-1alpha) and IL-1beta, and the expression of IL-1alpha, IL-1beta, tumour necrosis factor alpha (TNFalpha), IL-6 and IL-8 mRNA. These results suggest that the inhibitory effect of grepafloxacin is exerted, in part, at the gene transcription level.