[Toxoplasmic cyst and heart transplant: a case report of serological reactivation in an acute graft rejection context].

Annales de biologie clinique

PubMedID: 22565180

Desoubeaux G, Perret-Gallix K, Machet MC, Sirinelli A, Bailly E, Van Langendonck N, Chandenier J. [Toxoplasmic cyst and heart transplant: a case report of serological reactivation in an acute graft rejection context]. Ann Biol Clin (Paris). 2012;70(3):323-8.
We describe the case of a serological reactivation in a Toxoplasma-seropositive subject, following a cardiac transplantation transmitting cysts contained in the myocardial tissue. In a context of acute graft rejection, primary chemoprophylaxis enables to avoid onset of opportunistic toxoplasmosis, emerging with immunodepletion performed by high-dose steroids. Then, we draw up a brief review of the bibliographical literature about pathophysiological mechanisms of toxoplasmic reactivation in heart transplants.